Among the contenders for the Golden Bear top film award is Steven Soderbergh's Side Effects, which stars Jude Law and Catherine Zeta-Jones.
Soderbergh has said that Side Effects is to be his last movie, and it tackles the world of prescribed drugs, with Law playing a Manhattan doctor who tries to help a depressed wife by giving her a new superdrug.
Also in contention in Berlin is Prince Avalanche, starring Paul Rudd and the fracking drama Promised Land, which features Matt Damon.
New Dreamworks 3D animation The Croods has also debuted at the festival, with Nicola Cage, Ryan Reynolds and Emma Stone among those providing voices in the prehistoric comedy.
The Berlin prize can raise the profile of low-budget films to a global audience and is an important event in the movie calendar.
Away from the bigger Hollywood films, the impact of Europe-wide austerity measures has provided inspiration for film-makers from countries hardest hit by the financial crisis.
Spanish film Ayer No Termina Nunca (Yesterday Never Ends) is set in 2017 when Spain has hit rock bottom, with more than seven million unemployed and three million homes empty because their owners cannot keep up payments.
Director Isabel Coixet says: "This film is a distillation of my confusion, of my impotence. Through the settling of scores by this couple, behind their pain, is the situation of Spain.
"Two years ago we were reading what was happening in Greece and now it's happening to us. Perhaps this film will serve to warn other countries."
In the Greek-Italian film I Kori (The Daughter), the crisis invokes fear, when a 14-year-old kidnaps the son of her father's business partner whom she blames for bankrupting him.
The hot favourite to take the Golden Bear is the comedy-drama Gloria, directed by Sebastian Lelio, which tells the story of a 58-year-old divorcee determined to live life to the full.
It is one of many films at the festival this year that have given centre-stage to an older woman in the lead role.
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